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Reduces or completely stops stress-related behavior including: barking, whimpering and whining, chewing, urination and defecation. Also reduces or eliminates separation anxiety. Calms dogs during thunderstorms and fireworks or when left home alone. D.A.P. mimics a natural reassuring pheromone produced by female dogs when nursing. Includes 48 ml refill bottle with Comfort Zone for plug in electrical diffuser.