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For use on dogs 6 months and older. Do not use on cats or animals other than dogs. May be toxic and potentially fatal if applied to or ingested by cats. Do not get this product in your dog's eyes or mouth. Repeat applications may be made if necessary, but do not apply more often than once every 3 weeks, except to reapply after shampooing the dog.To apply:Remove product tube from package.Holding tube with notched end pointing up and away from face and body, snap or cut off narrow end at notches.Invert tube over dog and use open end to part dog's hair.Squeeze tube firmly to apply all of the solution to the dog's skin.15 lbs. and Under: Apply one tube (1.0 ml) as a spot or stripe to the dog's back between the shoulder blades. Between 16 - 30 lbs.: Apply one tube (1.5 ml) as a spot or stripe to the dog's back between the shoulder blades. 31 lbs. to 60 lbs.: Apply the entire tube (3.0 ml) as a continuous stripe on the dog's back starting between the shoulder blades and ending directly in front of the base of the tail OR apply approximately half of the tube (1.5 ml) as a spot or stripe to the dog's back between the shoulder blades and apply the rest of the tube's contents (1.5 ml) as a spot or stripe to the dog's back directly in front of the base of the tail. Over 60 lbs.: Apply the entire tube (4.5 ml) as a continuous stripe on the dog's back starting between the shoulder blades and ending directly in front of the base of the tail OR apply approximately half of the tube (2.25 ml) as a spot or stripe to the dog's back between the shoulder blades and apply the rest of the tube's contents (2.25 ml) as a spot or stripe to the dog's back directly in front of the base of the tail.Active Ingredients: Permethrin: 45%, s-methoprene: 3%, Other Ingredients: 52%