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Innovative time-release system provides all day joint support when used as directed. Each tablet contains 400 mg Glucosamine HCl, 200 mg Chondroitin Sulfate, 20 mg Ester-C(reg) and 5 mg Manganese. Ingredients in All Day Time Release System help form layers of glucosamine in each tablet. These layers release slowly over time as they come in contact with the liquids of the gastrointestinal tract. As the moisture penetrates to the core of the tablet, the ingredients are released and absorbed into the bloodstream. Administer one tablet every 12 hours fo reach 50 lbs. of body weight. For dogs 25 - 50 lbs. give 1/2 tablet, for dogs 50 pounds or more give 1 tablet. Comes 60 tablets per bottle.Do not allow dog to chew the tablet. Tablet should be swallowed whole.